Univariate logistic regression analyses showed that SCD-plus criteria ‘age ≥ 60’ (OR 7.7 (95% CI 1.7–34.6)) and ‘APOE e4 carriership’ (OR 5.0 (2.0–12.8)) were associated with an increased risk of preclinical AD (Fig. 4), whereas ‘memory specific decline’, ‘onset of complaints within 5 years’, ‘worse performance than other of the same age’, and ‘informant reports decline’ were not (Table 3). The gene discussed is APOE; the disease is Alzheimer disease.