F2R and neoplasm: Immunohistochemical assay of tumor tissues revealed that PLC-PAR1 and HepG2/M/PAR1 overexpressing tumors exhibited high expression levels of VEGFR1, VEGFR2, VE-cadherin, and vimentin and a low expression level of E-cadherin while Twist1 silence reversed the regulation effects of PAR1 (Fig. 6e).