PGF and preeclampsia: Given that the annual number of live-born and stillbirths in Germany in 2015 was 740,362 [39], which we estimate to arise from approximately 726,450 pregnancies, and that approximately 15% of pregnant women in Germany develop signs or symptoms of preeclampsia [40, 41], the use of the sFlt-1/PlGF test has the potential to provide an annual cost saving in Germany of more than €39 million.