Knockdown of ANXA2 expression by siRNA or shRNA significantly repressed the migration and invasion abilities of the KYSE30 and KYSE150 ESCC cell lines (Fig. 1c and 1d, Additional file 2: Figure S1) but did not substantially affect cell proliferation at the same time point (Additional file 3: Figure S2). Here, ANXA2 is linked to esophageal squamous cell carcinoma.