ANXA2 and esophageal squamous cell carcinoma: In contrast, our present study provides evidence that a high ANXA2 level promotes cell migration and invasion in the ESCC cell lines KYSE30, KYSE150 and KYSE180 in vitro and metastasis in vivo, suggesting that upregulation of ANXA2 plays critical roles in the progression of ESCC by conferring more aggressive phenotypes on tumor cells.