ANXA2 and esophageal squamous cell carcinoma: Considering that phosphorylation modification of certain amino acids, such as Tyr23 or Ser25 (counting Ser1 as the first amino acid), affects the cellular localization and function of ANXA2 [28], we investigated the influence of the phosphorylation status on ANXA2 localization through exogenous expression of different ANXA2 mutants in ESCC cells.