Furthermore, the release of tumor necrosis factor (TNF)-α, IL-1α/β and IL-6, can induce an immune response against the tumor and increase the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) by the immune cells infiltrating the tumor microenvironment that have a destructive effect on the tumor cells [12, 13]. The gene discussed is IL6; the disease is neoplasm.