This is in contrast to the experience in patients with R/R FLT3-ITD AML, where lower doses of quizartinib have revealed effective kinase inhibition and demonstrated that quizartinib monotherapy at a target dose of 60 mg is clinically efficacious and has reduced toxicity risk, consistent with quizartinib selectivity and potency against FLT3 [26]. This evidence concerns the gene FLT3 and acute myeloid leukemia.