Dysregulated RTK signaling, such as KIT or platelet-derived growth factor receptor (PDGFR) alpha overactivation in gastrointestinal (GI) stromal tumors (GIST) [4, 5] or RET activation in thyroid tumors [6], has been observed across a broad spectrum of solid tumors [7–12] and is implicated in both tumorigenesis and cancer progression. The gene discussed is PDGFRA; the disease is gastrointestinal stromal tumor.