LEP and obesity due to melanocortin 4 receptor deficiency: Many possible explanations have been proposed for certain cancers: The change of hormonal system in insulin, insulin like growth factors, estrogens and other cytokines could be induced by diabetic condition, which may affect the breast cancer risk; the increased production of leptin and the decreased production of adiponectin caused by both obesity and T2DM may cause similar risks for breast cancer [15].