Obesity is being increasingly recognized as sub-clinical inflammation and accordingly contributes to the increase of adipose tissue infiltration of inflammatory components including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP), all of which have shown to be associated with the development of breast cancer etiology [36]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.