IGFBP5 and osteoarthritis: Another study revealed that miR-27a expression is reduced in chondrocytes in osteoarthritis, and that this miRNA downregulates, albeit indirectly, two critical genes involved in the pathogenesis of osteoarthritis, namely insulin-like growth factor binding protein-5 (IGFBP-5) and matrix metalloproteinase-13 (MMP-13) [62].