The severe acute respiratory syndrome coronavirus (SARS-CoV) PLP removes the Lys63-linked ubiquitin chains of TRAF3 and TRAF6 [91]; the transmissible gastroenteritis virus (TGEV) PLP1 binds and deubiquitinates RIG-I [92]; and PRRSV NSP2, which contains the ovarian tumor (OTU) domain DUB and has been characterized as PLP2, interferes with the polyubiquitination process of IκBα to inhibit the activation of NF-κB [93]. This evidence concerns the gene PLP1 and neoplasm.