Interestingly, SDS-treated samples of amyloid plaques consist almost exclusively of Aβ [167], while samples that were treated with sarkosyl, which is a milder detergent than SDS, contain 11 proteins [168], most of which are known as the key AD-associated proteins: Tau, apolipoprotein E [169], serum amyloid P [170], and complement component 4 [171]. The gene discussed is MAPT; the disease is Alzheimer disease.