Importantly, and consistent with our experimental data (Figure 1, Figure 2, Figure 3 and Figure 4), a key overlap was observed among the PH and Fibrosis Networks, encompassing known miR-130/301 targets (LRP6, LRP8, PPARγ, and SP1), specific PAH hereditary factors (ENG, CAV1, SMAP9, and EIF2AK4), as well as multiple genes functionally related to miR-130/301 in PAH (COL1A1, COL3A1, LOX, YAP1, TAZ, and FN1). This evidence concerns the gene LRP6 and pulmonary arterial hypertension.