For example, Park et al. analyzed the correlation of Beclin1 expression and overall survival of 178 colon cancer patients who were receiving 5-fluorouracil therapy, and their results demonstrated that Beclin1 expression (hazard ratio was 1.82) could be a prognostic biomarker to guide optimal patient stratification [134]. The gene discussed is BECN1; the disease is malignant colon neoplasm.