Most importantly, co-inhibiting Hh signaling and autophagy by the combination of vismodegib and CQ could induce robust apoptosis in BaF3-BCR-ABLT315I cells which are resistant to CML drugs, such as imatinib and dasatinib, highlighting a possible way to overcome drug resistance in BCR-ABL+ CML patients [99]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.