Although upregulation of p53 has been reported in fibroblasts, hepatocytes, and HMECs following HCMV infection [12,15,115,116], the pUL122 binding to p53 in HCMV-infected fibroblasts and HMECs decreased p53 binding to DNA with inhibition of p53 activity and increased cell cycle progression and unchecked cell division [15,117]. Here, TP53 is linked to cytomegalovirus infection.