We have found that while ATGL is involved in TAG lipolysis in breast cancer cells exposed to prolonged starvation, its depletion is not sufficient to fully prevent lipid droplet breakdown and significantly reduce the pro-survival effect of lipid droplets [9], suggesting the involvement of other lipases and/or lipophagy in serum starvation-induced lipid droplet breakdown in breast cancer cells. This evidence concerns the gene PNPLA2 and breast cancer.