DGAT1 and obesity due to melanocortin 4 receptor deficiency: In fact, DGAT1-dependent lipid droplet formation mitigates lipotoxicity under various conditions of exogenous and endogenous lipid overload, including diet-induced obesity [144,145], cardiomyopathy [146,147], neuronal hypoxia [24], incubation with exogenous saturated and unsaturated FAs [9,27,144], and during periods of high autophagic flux [31].