Constitutive HIF signalling and abundant lipid droplet accumulation are hallmarks of clear-cell renal carcinoma and it was shown recently that HIF2α-dependent perilipin 2 (PLIN2) expression stimulates lipid droplet accumulation, protects from ER stress, and promotes cell proliferation and xenograft tumour growth [26]. Here, PLIN2 is linked to clear cell renal carcinoma.