Other inhibitors and activators of ATGL, such as perilipin 5, G0/S2 switch regulatory protein 2 (G0S2), and abhydrolase domain-containing protein 5 (ABHD5/CGI-58), whose roles in cancer are currently under investigation [189,190,191,217,218], could have an important impact on lipid droplet metabolism in hypoxic cancer cells. The gene discussed is PNPLA2; the disease is cancer.