In isolation, experimental data craft a convincing argument that the relationship between MDSCs and TAMs or TAM-like cells may be potentially beneficial in application to pulmonary hypertension: the MDSC-to-TAM cross-talk facilitates an increase in IL-10 production, a subsequent decrease in IL-12 secretion, and an overall activation of FoxP3 + Treg populations [134]. This evidence concerns the gene IL10 and pulmonary arterial hypertension.