ERBB2 and neoplasm: Fig 2A and 2B shows that the HER2-LLC1 cells exhibited a reduced tumor growth and an about 50% reduction in the engraftment ability in wt mice relative to HER2-transgenic/tolerant mice, quantified as reduced tumor growth at d 25 (Fig 2E), and in the Kaplan-Meier survival curves (Fig 2F). In contrast, when the wt-LLC1 cells were implanted in the two types of mice, there was no substantial difference (Fig 2C–2F).