TNF and rheumatoid arthritis: The effects of tumor necrosis factor (TNF) blockers on bone have shown contrasting results; a study of 30 RA patients treated with TNF blockers in addition to methotrexate and prednisolone, reported an increase in LS BMD of 0.2% and 0.1% at the hip compared to a decrease in LS BMD of -0.8% and -0.6% at the hip in a control group of 10 patients who received only methotrexate and prednisolone [18].