CYP2E1 and obesity due to melanocortin 4 receptor deficiency: CYP2E1 up-regulation has been associated to obesity, fatty liver, and NASH in both humans and rodents and correlates with NAFLD severity [50] and progression of liver steatosis to NASH: CYP2E1 up-regulation leads to enhanced ROS production, with an increase of lipid peroxidation and inflammation [51].