Examples include mutations in ELN,7encoding elastin, COL3A1,8encoding collagen type 3-α1, microfibril-associated protein 5,9or FBN1, encoding fibrilin1, and responsible for Marfan syndrome.10Additionally, mutations in genes encoding proteins required for elastogenesis and collagen metabolism such as EFEMP211and LOX12promote TAA. Here, ELN is linked to Marfan syndrome.