The miR‐181 pointed out here has been revealed to affect different aspects of cell life activities, including cell proliferation, cell differentiation and cell death.12, 13 Furthermore, miR‐181b was discovered to inhibit NF‐κB‐mediated endothelial cell activation by lowering the expression of importin‐α3 (IPOA3), a key protein assisting in translocation of NF‐κB from cytoplasm to nucleus.14 Notwithstanding, the role of miRNA‐181b in chronic inflammatory disease, such as atherosclerosis, has not been examined. This evidence concerns the gene NFKB1 and atherosclerosis.