Also ANRIL was capable of binding to PRC‐associated protein (ie, Yin Yang 1) to induce or restrain genetic expressions (eg, IL6 and IL8) that were related with inflammatory responses.35, 36, 37 Thus, it was quite acceptable that ANRIL could act on NF‐κB signalling to induce inflammation, thereby generating CAD‐specific cell activities (Figures 3, 4, 5, 6, 7, 8). This evidence concerns the gene NFKB1 and coronary artery disorder.