Also ANRIL was capable of binding to PRC‐associated protein (ie, Yin Yang 1) to induce or restrain genetic expressions (eg, IL6 and IL8) that were related with inflammatory responses.35, 36, 37 Thus, it was quite acceptable that ANRIL could act on NF‐κB signalling to induce inflammation, thereby generating CAD‐specific cell activities (Figures 3, 4, 5, 6, 7, 8). The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.