HDAC1 and cancer: Acetylation, especially histone acetylation, plays a role in regulating gene expression.9 Alteration of histone 3 and 4 acetylation level has been observed in a variety of cancers, including cervical cancer.10, 11 Histone deacetylase 1 (HDAC1) and HDAC2 are up‐regulated in cervical dysplasia and invasive cervical carcinoma.12 In cervical cancer HeLa cells, down‐regulation of HDAC2 expression inhibited cell proliferation and induced cell cycle arrest.10 HPV E7 has been reported to modulate histone acetylation through several mechanisms.