Knockdown of TRIM28 or TRIM44 suppresses the tumorigenesis by down‐regulating the Wnt/β‐catenin signalling pathway.25, 26 β‐Catenin can also be triggered by TRIM65 via enhancement of the ubiquitination of Axin1 in the progression of hepatocellular carcinoma.27 In the present study, we found that β‐catenin was down‐regulated by TRIM32 knockdown in SGC7901 and AGS cells and was up‐regulated in MKN28 cells with TRIM32 overexpression. Here, TRIM28 is linked to hepatocellular carcinoma.