Some experimental studies support the notion that HFD‐induced obesity exacerbates cerebral pathological alterations and the accompanying cognitive deficit in APP transgenic mice (Ho et al., 2004) while other claim for no effect (Kesby et al., 2015) or even improvement of memory in mice (Coscina, Yehuda, Dixon, Kish, & Leprohon‐Greenwood, 1986). This evidence concerns the gene APP and Obesity.