It is clear that ChREBP plays important roles in modulating the process of glycolysis and lipogenesis.23 Iizuka et al reported that the ChREBP knockout mice showed reduced glycolysis and lipogenesis and exhibited insulin resistance,24 whereas Benhamed et al showed that the ob/ob mice with ChREBP deletion exhibited reduced lipogenesis and improved insulin sensitivity. The gene discussed is INS; the disease is Insulin resistance.