PTEN and cancer: Studies have demonstrated that cellular senescence is a natural barrier in the development of human cancer.23, 24 Induction of senescent‐like growth arrest has become a new strategy for anticancer treatment.25 Thus, these results have important implications for matrine in the treatment of GBM, particularly due to the fact that aberrant signaling of PI3K/AKT occurs in GBM through the frequent loss of the tumor suppressor gene PTEN.