We demonstrate that matrine exerts a potent antitumor effect on GBM cells primarily through the induction of cellular senescence and inhibition of one of the main pathways corrupted in GBM, PI3K/AKT.11, 12, 13, 14 These results indicate that matrine has promise as a chemotherapeutic agent in the treatment of GBM patients. This evidence concerns the gene AKT1 and glioblastoma.