NBM primitive cells showed lower basal levels of ROS than their CML counterpart, this could indicate higher levels of reduced glutathione in normal populations, which would make normal primitive cells resilient to PTL and DMAPT effect as has been observed in CD34+ cells from AML samples,13 and proves a key mechanism to be exploited and further studied. Here, PNLIP is linked to chronic myelogenous leukemia, BCR-ABL1 positive.