Furthermore, basal ROS levels were higher in CML primitive cells (Figure 3B), such as has been previously reported.7 Also, NBM cells responded differently to treatment, ROS levels in CML CD34+lin− were increased while in the normal counterpart were reduced, suggesting a higher resilience to oxidant stress and an antioxidant mechanism in the normal population. This evidence concerns the gene CD34 and chronic myelogenous leukemia, BCR-ABL1 positive.