PGR and neoplasm: Significant differences between groups in clinical and pathological characteristics (age, tumour type, DCIS, TNM stage, receptor status (oestrogen receptor, progesterone receptor, HER2), lymphovascular invasion, margins) were reported in four studies32, 34, 35, 43 of BCS versus mastectomy for MIBC, and in four studies27, 37, 39, 43 of BCS for MIBC versus unifocal cancers (Table S3, supporting information).