The top upstream regulators in the bone cancer pain model are shown inFigure 8A (p-value of overlap <0.05, ANOVA) and includes cytokine IFNG (activation z-score 1.9); growth factor LEP (activation z-score 0.4); and transcription regulator NFE2L2 (activation z-score 1.9). The gene discussed is NFE2L2; the disease is bone neoplasm.