In contrast, leptin level was significantly positively correlated with Risser sign (r = 0.378; p < 0.01), weight (r = 0.325; p < 0.01), corrected BMI (r = 0.252; p < 0.05), corrected height (r = 0.264; p < 0.001), and age (r = 0.302; p < 0.05), while initial Cobb angle of AIS girls correlated neither with ghrelin level nor with leptin level. The gene discussed is GHRL; the disease is androgen insensitivity syndrome.