More importantly, according to the analysis of the correlations between physical characteristics and leptin/ghrelin levels, leptin level significantly correlated with age, Risser sign, weight, and other growth parameters, and ghrelin level negatively correlated with Risser sign, age, and corrected BMI, indicating that serum leptin and ghrelin levels may be risk factors in curve progression AIS girls. This evidence concerns the gene GHRL and androgen insensitivity syndrome.