The results of the pooled analysis showed that low PINX1 expression was associated with lymph node metastasis (OR: 2.23, 95.0% CI: 1.35–3.70; P = 0.002) and advanced TNM stage (OR: 2.43, 95.0% CI: 1.29–4.57; P = 0.006). The gene discussed is PINX1; the disease is metastatic malignant neoplasm in the lymph nodes.