In a subgroup analysis of tumor type, low PINX1 expression was associated with significantly poorer OS for colorectal cancer (HR: 2.28, 95.0% CI: 1.46–3.56; P < 0.001) and non-small cell lung cancer (HR: 1.48, 95.0% CI: 1.06–2.08; P = 0.023). Here, PINX1 is linked to colorectal cancer.