Significantly, 5-Aza-CdR inhibited proliferation and induced apoptosis of SKOV3 cells due to the reversal of promoter hypermethylation of genes, including Wnt5a. Based on our results, Wnt5a demethylation may be a new target for the treatment of epithelial ovarian cancer. The gene discussed is WNT5A; the disease is ovarian carcinoma.