Drugs which increase the number of LDL receptors (LDLR) such as statins and PCSK9 inhibitors are more effective in reducing LDL levels than Lp(a) levels because Lp(a) competes poorly with LDL for binding to LDLR [22]. Additionally, Lp(a) levels are elevated in subjects with familial hypercholesterolemia [23]. The gene discussed is LDLR; the disease is familial hypercholesterolemia.