ACE and diabetes mellitus: The elderly are at greatest risk because of decreased glomerular filtration rate, comorbid conditions (CV disease, hypertension, or diabetes), and taking associated drugs (e.g., β-blockers, angiotensin-converting enzyme (ACE) inhibitors, or diuretics; Huerta, Castellsague, Varas-Lorenzo, & Rodríguez, 2005; Weir, 2002).