TSHR and ovarian neoplasm: For the remaining three regions, the 50 kb selected region on chromosome 5 includes two genes; the TSHR locus involved in metabolic regulation and reproduction process (Yoshimura et al., 2003; Hanon et al., 2008; Rubin et al., 2010) and GTF2A1, a candidate biomarker for detecting ovarian tumor (Huang et al., 2009).