Although IgA aCL antibodies have been associated with poliabortivity and fetal deaths in women with primary APS, systemic lupus erythematosus, and unexplained recurrent spontaneous abortion (23), in the present study we showed that the IgA isotypes of the aCL is detectable only in 4% of SN-APS patients. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.