However, this finding is not surprising, since Žigon et al., who studied the prevalence and clinical association of aPS/PT in patients with a history of pregnancy complications relevant to APS, showed positive of aPS/PT in about 13% of OAPS patients; aPS/PT were the only antibodies associated with early recurrent pregnancy loss, as well as with late pregnancy morbidity and prematurity (21). Here, F2 is linked to autoimmune polyendocrinopathy.