In order to overcome the limits imposed by conventional tests, we employed a different methodological approach for detection of aCL, TLC-immunostaining, showing the presence of aCL in more than three-quarters (76%) of patients with obstetric SN-APS; these data confirmed the previous results obtained in patients with different records of SN-APS, but also in a case of catastrophic APS (15, 17). Here, ACLY is linked to autoimmune polyendocrinopathy.