Although IgA aCL antibodies have been associated with poliabortivity and fetal deaths in women with primary APS, systemic lupus erythematosus, and unexplained recurrent spontaneous abortion (23), in the present study we showed that the IgA isotypes of the aCL is detectable only in 4% of SN-APS patients. This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.