PROS1 and hyperinsulinemic hypoglycemia, familial, 4: All patients were tested for common inherited thrombophilic defects: 18/61 (29.5%) patients presented mutation of MTHFR in heterozygosity, with normal levels of homocysteine; 6/61 (9.8%) mutation of MTHFR in homozygosity, with normal levels of homocysteine; 1/61 (1.6%) mutation of V factor of Leiden in homozygosity; 1/61 (1.6%) protein S deficiency.