CD38 and plasma cell myeloma: Analogously, significantly lower CD38-expression was found for t(11;14) in asymptomatic myeloma, associated in this entity with slower progression (data not shown), and hyperdiploidy in symptomatic patients; here with different prognostic directions: while hyperdiploidy is associated with good/standard risk (50, 51), low CD38-expression is associated with adverse prognosis.