NOD2 and leprosy: SNP markers 597 C/T (rs3804099) and a 280 bp-length microsatellite of TLR2 have been associated with protection and increased risk of leprosy reactions, respectively (45) Another sensing molecule consistently associated with leprosy is the nucleotide-binding oligomerization domain 2 (NOD2), a cytoplasmic receptor responsible for recognizing intracellular pathogens via their peptidoglycan components of the bacterial cell wall.