KCNH2 and cardiac arrhythmia: However, it is also clear that the sole use of steady-state hERG block assays is insufficient to predict arrhythmia risk, and thus studies are beginning to simulate the effects drug-binding kinetics and state-specific binding, which have been shown to affect electrophysiological outcomes (Lee W. et al., 2016; Dutta et al., 2017; Ellinwood et al., 2017b; Li et al., 2017).