Here, in agreement with previous findings, we provide initial evidence that GSKJ4 compound increases the global level of H3K27me2/3 methylation and acts as a small molecule inhibitor of the proliferation of myeloid leukemia cells, mechanistically suggesting that GSKJ4 might have anticancer activity by inhibiting demethylases JMJD3 and UTX. Here, KDM6B is linked to myeloid leukemia.