Interestingly, the CCND1 gene maps to the same chromosomal region and appears significantly overexpressed in the ADC versus SCC samples of the in-house TMA (data unshown), in accordance with previous reports.33,34 Hence, the expression of genes harboured in the 11q13 region might be regulated by the same epigenetic events occurring at this locus and resulting in the co-expression/repression of neighbouring genes. The gene discussed is CCND1; the disease is AIDS dementia complex.