ARRB1 gene is located on the chromosomal band 11q13 and is altered in 5.2% of lung ADC cases and in 1.7% of lung SCC (information from the cBioPortal for cancer genomics).31,32 However, the prevalence of these alterations cannot explain the observed differences in beta-arrestin-1 expression. The gene discussed is ARRB1; the disease is cancer.