Dysregulation of adipocytokines/adipokines, such as hypoadiponectinemia, has been reported previously [40], and the high levels of inflammatory cytokines in the accumulated visceral fat could result in systemic low-grade inflammation, insulin resistance, microalbuminuria [41, 42], arterial stiffness [43], and atherosclerotic cardiovascular diseases [40, 44]. The gene discussed is INS; the disease is adiponectin deficiency.