CRP and Increased total leukocyte count: Moreover, other prognosis factors have been described in oncology for advanced cancer patients, such as anorexia–cachexia syndrome, delirium, leukocytosis, lymphocytopenia, levels of C-reactive protein [28] or combinations of criteria, including Karnofsky index, number of metastatic sites, levels of serum albumin and lactate dehydrogenase (LDH) concentration [29].