For example, a previous study has shown that a complete ablation of CRB1 and CRB2 proteins in mouse retina simulate a serious retinal disorder in human, and produces a dysregulation in the proliferative signaling pathway YAP/Hippo in the retinal progenitor cells29.This hypothesis is consistent with many independent studies demonstrating the association between CRB proteins and different cell signaling pathways related with cell proliferation, differentiation and cell-cell adhesion have been proposed and studied in different organisms. This evidence concerns the gene CRB2 and retinal disorder.