In our present work, we determined that ALPS can effectively improve dyslipidaemia by negative regulation on LDL-C and TC levels and positive regulation on HDL-C level, alleviate hepatic lipid metabolism disorder by reducing hepatic TC and TG, mitigate oxidative stress via enhancing antioxidant enzyme activities and decreasing lipid peroxide products and improve effects from alcohol metabolism disorder by suppressing CYP2E1 activity in mice with acute alcohol-induced hepatic injury. Here, CYP2E1 is linked to inherited lipid metabolism disorder.