TP53 and neoplasm: Crucially, when we sought associations between CIC, p53 and large-scale genomic aberrations in a set of tumours for which we also held full genomic characterization, we observed the predicted association between CIC and somatic copy number aberrations, but found no association with single nucleotide variants, consistent with a model in which CIC affects chromosome integrity/segregation but not the fidelity of DNA replication.