Prominent examples include the association between familial hypercholesterolemia [Online Mendelian Inheritance in Man (OMIM) identifier 144010]; increased risk of ischemic heart disease and genetic variants in APOB (17); and the association of the APOA5 variants with hypertriglyceridemia (OMIM identifier 145750) in African-Americans, Spanish, and Caucasians (18); as well as APOE genotypes with circulating lipid levels and with coronary risk (19, 20). The gene discussed is APOA5; the disease is hypertriglyceridemia.