APOC3 and hypertriglyceridemia: In contrast, no common deleterious variant was detected in APOC2 and APOC3. Thus, rare variants and CNVs are expected to explain the entire functional variability of APOC3, a gene for which loss-of-function mutations have been strongly linked with favorable lipid profiles (64), and of APOC2, which has been consistently associated with hypertriglyceridemia (65).