2-arachidonoyl glycerol (2-AG), the most abundant endocannabinoid, has been illustrated to play a significant role in protecting neurocytes from inflammatory injuries, such as stimuli of interleukine-1 beta (IL-1β), lipopolysaccharide (LPS), and β-amyloid in models of neurodegenerative diseases [11, 12]. This evidence concerns the gene IL1B and neurodegenerative disease.