Methylation levels at the FOXP3 locus was increased in LN CD4+ T cells from patient with muscle invasive pT2 compared to both non-muscle invasive pTa-Tis staged patients and to the cells from patients with perivesical infiltrating tumours (pT3) (p < 0.05 for both) (Fig. 6c). The gene discussed is CD4; the disease is neoplasm.