The level of VEGFA in the lungs of 4T1 breast cancer-bearing mice was transiently increased in the 3rd week of the disease (Fig. 5e) and such a local rise in VEGFA has been recently associated with oscillatory turbulent flow (Lena Claesson-Welsh, personal communication, the 2nd Nov, 2016) that could activate the mechanoreceptors on endothelial cells. Here, VEGFA is linked to breast carcinoma.