The signaling pathways are mediated by growth factors (EGF, HGF, TGFB3, BMP4), cytokines (TNF, SLIT2) and specific receptors (CD3E, CD28, FCGR3B, CSF2R), suggesting greater influence of activated fibroblasts in MM compared to the condition of MGUS. Here, TGFB3 is linked to Miyoshi myopathy.