The signaling pathways are mediated by growth factors (EGF, HGF, TGFB3, BMP4), cytokines (TNF, SLIT2) and specific receptors (CD3E, CD28, FCGR3B, CSF2R), suggesting greater influence of activated fibroblasts in MM compared to the condition of MGUS. The gene discussed is BMP4; the disease is Miyoshi myopathy.